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The first report on the atom transfer radical polymerization of an optically active acidic monomer based on L-phenylalanine.

Abstract

For the first time, acidic monomer chiral N-acryloyl-L-phenylalanine was polymerized directly by atom transfer radical polymerization under mild conditions. Controlled polymerization was carried out in pure water, methanol/water mixture, or pure methanol using water-soluble initiators, such as 2-hydroxyethyl-2′-methyl-2′-bromopropionate and sodium-4-(bromomethyl)benzoate at room temperature. The corresponding optically active biocompatible amino acid-based homopolymers were obtained in good yields with narrow molecular weight distributions.